Endocrine Abstracts

Significant hyperglycaemia suppresses beta cell replication and cell cycle progression. Acute beta cell failure is caused by several mechanisms involving oxidative and endoplasmic stress leading to DNA damage response (collectively termed glucotoxicity) (1). Short-term glycaemic control unmasks the regenerative potential of beta cells, leading to recovery and potentially weaning off Insulin therapy (1, 2, 3). We present a case of a 62-year-old woman with ...